What Time Grey’s Anatomy Season 21, Episode 1 Releases

ABC’s popular medical drama, Grey’s Anatomy, is set to premiere on Thursday, September 26th, 2024. Crowned as the longest-running primetime television drama, Grey’s Anatomy returns this fall for its 21st season, as more drama and chaos ensue at Grey Sloan Memorial. The new entry in the series will pick up from Grey's Anatomy season 20's ending after three doctors were fired after defying Catherine’s authority, forcing her to take matters into her own hands. Season 21 will also follow the return of a familiar face, doctors facing new complicated challenges, and Catherine entering her villainous era.

The dynamic between Meredith Grey and Catherine Fox will be fun to watch this season, because both are headstrong women who will continuously butt heads as Meredith fights to continue work on her research and the reinstatement of Amelia, Owen, and Teddy’s jobs. The complexities of Catherine’s relationship are expected to not only affect Meredith, but also other staff members after she threatens to replace them all, resulting in Miranda Bailey challenging Catherine’s actions. Outside the hospital drama, the doctors and interns continue facing their own personal challenges and dilemmas, while trying to balance a stressful job that requires no distractions.

Grey's Anatomy Season 21's Premiere Releases At 10pm ET

Part 1: The Countdown Begins

Starting on September 26, 2024, Grey’s Anatomy’s season 21 will premiere on ABC at 10 p.m. ET/PT, following new episodes every Thursday night. Although questions circulate about Grey's Anatomy's future and if season 21 will be its last, there’s no confirmation of saying goodbye to this beloved team anytime soon.

Grey Sloan Memorial’s favorite doctors are set to return, enduring new challenges in their personal lives. The new season of Grey’s Anatomy will also be available to stream the next day on the ABC app, ABC.com, or Hulu. All past 20 seasons are available to currently stream on Hulu, Netflix, Philo and fuboTV.

How Many Episodes Grey's Anatomy Season 21 Has

What to Expect and Episode Count

Debbie Allen as Catherine Fox in Grey's Anatomy season 21's teaser trailer pointing angrily offscreen

Ellen Pompeo as Meredith Grey and Jesse Williams as Jackson Avery in Grey's Anatomy season 21's teaser trailer

The New Grey's Anatomy Cast Looking Shocked in Season 21

Debbie Allen as Catherine Fox in Grey's Anatomy season 21's teaser trailer pointing angrily offscreen

Ellen Pompeo as Meredith Grey and Jesse Williams as Jackson Avery in Grey's Anatomy season 21's teaser trailer

The New Grey's Anatomy Cast Looking Shocked in Season 21

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Debbie Allen as Catherine Fox in Grey's Anatomy season 21's teaser trailer pointing angrily offscreen

Ellen Pompeo as Meredith Grey and Jesse Williams as Jackson Avery in Grey's Anatomy season 21's teaser trailer

The New Grey's Anatomy Cast Looking Shocked in Season 21

Debbie Allen as Catherine Fox in Grey's Anatomy season 21's teaser trailer pointing angrily offscreen

Ellen Pompeo as Meredith Grey and Jesse Williams as Jackson Avery in Grey's Anatomy season 21's teaser trailer

The New Grey's Anatomy Cast Looking Shocked in Season 21

Close

Debbie Allen as Catherine Fox in Grey's Anatomy season 21's teaser trailer pointing angrily offscreen

Ellen Pompeo as Meredith Grey and Jesse Williams as Jackson Avery in Grey's Anatomy season 21's teaser trailer

The New Grey's Anatomy Cast Looking Shocked in Season 21

Debbie Allen as Catherine Fox in Grey's Anatomy season 21's teaser trailer pointing angrily offscreen

Ellen Pompeo as Meredith Grey and Jesse Williams as Jackson Avery in Grey's Anatomy season 21's teaser trailer

The New Grey's Anatomy Cast Looking Shocked in Season 21

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The return of Grey’s Anatomy, season 21, will consist of 18 episodes total. This season will run much longer compared to season 20, which only included an episode count of 10 due to the previous writers’ and actors’ strike.

Due to the strike concluding, this season, along with possible future seasons, can move forward with more episodes for a longer run and more stories to include.

What To Expect From Grey's Anatomy Season 21, Episode 1

Storyline Hints

Kali Rocha as Sydney Heron in Grey's Anatomy seasons 2 and 21-1

Kali Rocha as Sydney Heron, Niko Terho as Lucas Adams and Alexis Floyd as Simone Griffiths in Grey's Anatomy season 21's trailer

Meredith at her desk being approached by someone with a folder in Grey's Anatomy season 21

Kali Rocha as Sydney Heron in Grey's Anatomy seasons 2 and 21-1

Kali Rocha as Sydney Heron, Niko Terho as Lucas Adams and Alexis Floyd as Simone Griffiths in Grey's Anatomy season 21's trailer

Meredith at her desk being approached by someone with a folder in Grey's Anatomy season 21

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Kali Rocha as Sydney Heron in Grey's Anatomy seasons 2 and 21-1

Kali Rocha as Sydney Heron, Niko Terho as Lucas Adams and Alexis Floyd as Simone Griffiths in Grey's Anatomy season 21's trailer

Meredith at her desk being approached by someone with a folder in Grey's Anatomy season 21

Kali Rocha as Sydney Heron in Grey's Anatomy seasons 2 and 21-1

Kali Rocha as Sydney Heron, Niko Terho as Lucas Adams and Alexis Floyd as Simone Griffiths in Grey's Anatomy season 21's trailer

Meredith at her desk being approached by someone with a folder in Grey's Anatomy season 21

Close

Kali Rocha as Sydney Heron in Grey's Anatomy seasons 2 and 21-1

Kali Rocha as Sydney Heron, Niko Terho as Lucas Adams and Alexis Floyd as Simone Griffiths in Grey's Anatomy season 21's trailer

Meredith at her desk being approached by someone with a folder in Grey's Anatomy season 21

Kali Rocha as Sydney Heron in Grey's Anatomy seasons 2 and 21-1

Kali Rocha as Sydney Heron, Niko Terho as Lucas Adams and Alexis Floyd as Simone Griffiths in Grey's Anatomy season 21's trailer

Meredith at her desk being approached by someone with a folder in Grey's Anatomy season 21

Expectations from a new Grey’s Anatomy season are anything but boring or ordinary, often including unique cases for the doctors to handle, and new challenges to perfectly set up the new season’s storyline. Grey’s Anatomy's first episode will follow the aftermath of Catherine firing some of the best doctors known at Grey Sloan Memorial, while also stirring up more complications for Meredith and Amelia’s research.

Catherine continuing to create chaos everywhere she goes also leads to a heated confrontation between Catherine and Bailey that could lead to harsh consequences for Bailey’s actions after one cold, hard slap is heard around the hospital.

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